Ozone therapy and pressure-pulse therapy in Ménière's disease.

The aim of this study was to evaluate the usefulness of ozone and pressure-pulse therapies in treating Ménière's disease. Using objective otoacoustic emissions and short-increment sensitivity index (SISI) tests together with subjective anamnesis, we tested 15 patients (8 men, 7 women) who had suffered from Ménière's disease for 1-3 years and had permanent sensorineural hypoacusis; we compared results before and after treatment. We performed ozone therapy and pressure-pulse treatments simultaneously for one 10-minute session each day for 10 consecutive days. After treatment, both otoacoustic-spontaneous and transiently evoked emissions and SISI test results exhibited no statistically significant changes. However, the subjective state of the patients was clearly improved. The frequency, severity of attacks, and tinnitus decreased. The mechanism of such an improvement is discussed.